Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α

Abstract

This study provides new insights into the role of HIF-1α in the development of peribronchial angiogenesis and inflammation in a murine model of allergic airway disease. These findings indicate that strategies to reduce activation of macrophage derived HIF-1α may be used as a target to improve asthma pathology.