Endocrinology · 1986 · 111 citations · 31 references
MedicineEndocrinologyMolecular BiologyBone MetabolismCalcium HomeostasisGene ExpressionBone EndocrinologyBone PhysiologyBone TissueCalcium EndocrinologyCalcium SignalingEndocrine Regulation Of CalciumBone Resorption InhibitionCalcitonin BiosynthesisCalcitonin Gene ExpressionCalcitonin Gene-related Peptide PhysiologyCalcitonin Receptor ExpressionHypocalcemic Actions Of CalcitoninReceptor-mediated Calcium SignalingReceptors
Recent studies of rat and human calcitonin (CT) gene expression have uncovered a diversity of secretory peptides. Here we report the results of testing two such non-CT secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide, CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro experiments are consistent with the idea that CT gene-related peptide is acting at CT receptors in bone.
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Calcitonin gene-related peptide is a potent vasodilator
Susan D. Brain, T.J. Williams, John R. Tippins et al. · Nature · 1985 · 2.1K citations
Isolation and characterization of human calcitonin gene-related peptide
Howard R. Morris, Maria Panico, Tony Etienne et al. · Nature · 1984 · 426 citations