The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA synthesis

Metabolism of Isolated Fat Cells

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Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Bentley Cheatham, Chris J. Vlahos, Lynn Cheatham et al. · Molecular and Cellular Biology · 1994 · 1K citations · Full text

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Phosphatidylinositol 3-Kinase Encoded by Yeast <i>VPS</i> 34 Gene Essential for Protein Sorting

Peter Schu, Kaoru Takegawa, Michael Fry et al. · Science · 1993 · 921 citations

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Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara et al. · Journal of Biological Chemistry · 1994 · 919 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17