HOMOIOPLASTIC ADRENAL GRAFTS TO THE CEREBRAL CORTEX OF THE RAT

Abstract

THE conclusion that the adrenal gland, in contrast to other tissues in the body, was exceedingly resistant to transplantation (Oldberg, 1929) has been followed by a large number of critical studies. These have shown that grafts of this organ can be made which will give protection against the insufficiency resulting from complete adrenalectomy. Among the sites chosen for implantation the following have been particularly useful: the intramuscular area (Jaffe and Plavska; 1926; Dornfeld, 1937; Wyman and turn Suden, 1937; 1941), the ovary (Pencharz and Olmsted, 1931; Martin, 1932; Ingle and Higgins, 1938; Eversole, Edelmann and Gaunt, 1940), the kidney (Eversole, et al., 1940), the eye (Turner, 1939; Turner, Haffen and St. Amant, 1939), and the pinna of the ear (Kroc, 1942). Most of this work has been done with the rat, and while it has consisted largely of autoplastic transplantations, homoioplastic grafts have also been found successful. Recently Katz and Mainzer (1941) have reported on the use of grafts in the treatment of Addison's disease.