Interrelationships among genetic <i><scp>C</scp>677<scp>T</scp></i> polymorphism of 5,10‐methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic <i>p53</i> oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma

Abstract

Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients. The CT/TT genotypes correlated with lower risks of late-stage HCC and a favorable survival of HCC patients, depending on p53 oxidative lesions or RBC folate status.