Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step

Efficient Reagents for the Synthesis of 5-, 7-, and 5,7-Substituted Indoles Starting from Aromatic Amines:  Scope and Limitations

Jesús Ezquerra, Concepción Pedregal, Carlos José Einicker Lamas et al. · The Journal of Organic Chemistry · 1996 · 185 citations

Cross-coupling Reaction, Engineering, Aforementioned Indoles +15

Sonogashira coupling and cyclization reactions on alumina: a route to aryl alkynes, 2-substituted-benzo[b]furans and 2-substituted-indoles

George W. Kabalka, Lei Wang, Richard M. Pagni · Tetrahedron · 2001 · 169 citations

Cross-coupling Reaction, Heterocyclic, Sonogashira Coupling +4

Efficient Syntheses of KDR Kinase Inhibitors Using a Pd-Catalyzed Tandem C−N/Suzuki Coupling as the Key Step

Yuan‐Qing Fang, Robert Karisch, Mark Lautens · The Journal of Organic Chemistry · 2007 · 103 citations

Synthesis of 5-Substituted-1<i>H</i>-indol-2-yl-1<i>H</i>-quinolin-2-ones:  A Novel Class of KDR Kinase Inhibitors

Jeffrey T. Kuethe, Audrey Wong, Chuanxing Qu et al. · The Journal of Organic Chemistry · 2005 · 90 citations

Alcohol 30, Molecular Pharmacology, Medicinal Chemistry +15

Ligand-, copper-, and amine-free one-pot synthesis of 2-substituted indoles via Sonogashira coupling 5-endo-dig cyclization

Sanjay S. Palimkar, Pradeep Kumar, Rajgopal J. Lahoti et al. · Tetrahedron · 2006 · 79 citations

Cross-coupling Reaction, Engineering, 5-Endo-dig Cyclization +8