Mechanisms of Steatorrhea in the Zollinger-Ellison Syndrome

Abstract

Case Studies1 October 1967Mechanisms of Steatorrhea in the Zollinger-Ellison SyndromeROBERT M. VOGEL, M.D., L. DONALD WEINSTEIN, M.D., TEODORO HERSKOVIC, M.D., HOWARD M. SPIRO, M.D., F.A.C.P.ROBERT M. VOGEL, M.D.Search for more papers by this author, L. DONALD WEINSTEIN, M.D.Search for more papers by this author, TEODORO HERSKOVIC, M.D.Search for more papers by this author, HOWARD M. SPIRO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-816 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiarrhea is a prominent clinical feature of the Zollinger-Ellison syndrome (1). In approximately one half of the well-studied cases of non-beta islet cell adenomas diarrhea is associated with marked gastric hypersecretion and intractable peptic ulcer disease; it is within this group that steatorrhea and malabsorption occur (1-13). Although the gastric hypersecretion may be responsible for the diarrhea, the precise etiologic mechanism has not been fully elucidated. Theoretically, hyperacidity must lead to steatorrhea by two possible mechanisms: [1] inactivation of pancreatic enzymes, particularly lipase, by acid duodenal contents or [2] production of jejunal abnormalities. If this hypothesis is correct, drastic reduction...References1. SINGLETONKERNWADDELL JWFWR: Diarrhea and pancreatic islet cell tumor: report of a case with a severe jejunal mucosal lesion. Gastroenterology 49: 197, 1965. CrossrefMedlineGoogle Scholar2. MAYNARDPOINT EPWW: Steatorrhea associated with ulcerogenic tumor of pancreas. Amer. J. Med. 25: 456, 1958. CrossrefMedlineGoogle Scholar3. SANCHEZSOMMERS GCSC: Peptic ulcer diathesis with a mixed adenocarcinoma of pancreas: case report. Gastroenterology 38: 467, 1960. CrossrefMedlineGoogle Scholar4. 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GREGORYTRACY RAHJ: The preparation and properties of gastrin. J. Physiol. (London) 156: 523, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT M. VOGEL, M.D.; L. DONALD WEINSTEIN, M.D.; TEODORO HERSKOVIC, M.D.; HOWARD M. SPIRO, M.D., F.A.C.P.Affiliations: New Haven, ConnecticutFrom the Division of Gastroenterology, Department of Medicine, Yale-New Haven Hospital and Yale University School of Medicine, New Haven, Conn.This study was supported in part by grant FR-0038 to the Yale Clinical Research Center from the U. S. Public Health Service, Washington, D. C.Dr. Spiro was aided in this work by grant AM-5156-09 9070-41-48574, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Robert M. Vogel, M.D., Department of Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, Conn. 06510. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastric Secretion in Zollinger-Ellison SyndromeZollinger-Ellison Syndrome: Clinical Presentation in 261 PatientsPathophysiology of the Exocrine PancreasPathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome)The Malabsorption SyndromeDiarrhoea: mechanisms and treatment.A case of the Zollinger-Ellison syndrome associated with hyperplasia of salivary and Brunner's glandsEffects of brocresine on zollinger-ellison syndrome report of 2 casesDisturbances in Fat Digestion Induced by Acidic Jejunal pH Due to Gastric Hypersecretion in ManClinical Observations on MalabsorptionMalabsorptionDas Zollinger-Ellison-SyndromThe Zollinger-Ellison Syndrome with SteatorrheaPhysiologic responses to gastric acid hypersecretion in Zollinger-Ellison syndrome 1 October 1967Volume 67, Issue 4Page: 816-822KeywordsAdenomasDiarrheaEnzymesHospital medicineLipasesMedical servicesPeptic ulcersZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 October 1967 PDF downloadLoading ...