Bioactive Terpenoids from Octocorallia. 3. A New Eunicellin-Based Diterpenoid from the Soft Coral <i>Cladiella sphaeroides</i>

Abstract

A new diterpenoid, cladiellaperoxide ( 2 ), has been isolated from the soft coral Cladiella sphaeroides, together with the known diterpenoid cladiellisin ( 1 ). Their structures were characterized by NMR studies and chemical conversion. The absolute configurations of 1 and 2 have been elucidated by the modified Mosher method. Compound 2 showed lethality toward brine shrimp.