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Use of Carbenicillin and Polymyxin B for Therapy of Gram-Negative Bacilli Infections
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1971
Year
Severe InfectionsHealth SciencesAntibioticsAntimicrobial SusceptibilityMedicineGram-negative Bacilli InfectionsKlebsiella PneumoniaeSepsisAntimicrobial TherapyMicrobiologyInfection ControlTherapeutic TrialsPolymyxin BPharmacologyAntimicrobial ChemotherapyClinical MicrobiologyAntimicrobial ResistanceDrug Resistance
Twenty-one therapeutic trials with a combination of carbenicillin and polymyxin B were conducted for initial treatment of severe infections caused by gram-negative bacilli. Failure to respond to therapy was observed in 7 out of 13 patients with septicemia or bronchopneumonia. No serious toxicity of this antibiotic regimen was encountered.