Use of Carbenicillin and Polymyxin B for Therapy of Gram-Negative Bacilli Infections

Abstract

Twenty-one therapeutic trials with a combination of carbenicillin and polymyxin B were conducted for initial treatment of severe infections caused by gram-negative bacilli. Failure to respond to therapy was observed in 7 out of 13 patients with septicemia or bronchopneumonia. No serious toxicity of this antibiotic regimen was encountered.