Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells

The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms

R. M. J. Ings, James A. McFadzean, Walter Ormerod · Biochemical Pharmacology · 1974 · 207 citations

Biology, Other Micro-organisms, Unicellular Organism +7

Hypoxic Sensitizers: Radiobiological Studies at the Cellular Level

Eric J. Hall, Laurie Roizin-Towle · Radiology · 1975 · 202 citations

Radiobiological Studies, Radiation Effect, Hypoxic Cells +18

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

Jagjit K. Mohindra, Andrew M. Rauth · PubMed · 1976 · 181 citations

Cell Death, Redox Biology, Oxidative Stress +17

Selective chemotherapy of noncycling cells in an in vitro tumor model.

Robert M. Sutherland · PubMed · 1974 · 170 citations

Cell Death, Cellular Pharmacology, Pharmacotherapy +20

Metronidazole (“Flagyl”). A radiosensitizer of hypoxic cells

J.C. Asquith, Josh Foster, R. L. Willson et al. · British Journal of Radiology · 1974 · 119 citations

Radiation Effect, Hypoxic Cells, Radiation Biology +17