Concepedia

A Randomized Study of the Relative Pharmacokinetics, Pharmacodynamics, and Safety of Alirocumab, a Fully Human Monoclonal Antibody to <scp>PCSK</scp>9, After Single Subcutaneous Administration at Three Different Injection Sites in Healthy Subjects

Catherine Lunven, Tobias Paehler, Franck Poitiers, Aurélie Brunet, Jacques Rey, Corinne Hanotin, William J. Sasiela

Cardiovascular Therapeutics · 2014 · 57 citations · 8 references

DOIFull text

Open access

Abstract

These results suggest that alirocumab can be interchangeably injected in the abdomen, upper arm, or thigh.

References

8

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.1K citations

, , +19

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Marianne Abifadel, Mathilde Varret, Jean‐Pierre Rabès et al. · Nature Genetics · 2003 · 3K citations

, , +4

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

Evan A. Stein, Scott Mellis, George D. Yancopoulos et al. · New England Journal of Medicine · 2012 · 659 citations · Full text

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

Evan A. Stein, Dan Gipe, Jean Bergeron et al. · The Lancet · 2012 · 575 citations

, , +7

Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy

James M. McKenney, Michael J. Koren, Dean J. Kereiakes et al. · Journal of the American College of Cardiology · 2012 · 504 citations

, , +9