Silymarin Extraction from Milk Thistle Using Hot Water

Accelerated Solvent Extraction:  A Technique for Sample Preparation

B. E. Richter, Brian A. Jones, John L. Ezzell et al. · Analytical Chemistry · 1996 · 1.2K citations

Natural Sciences, Chemical Engineering, Chemistry +13

A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model.

M. Lahiri-Chatterjee, Säntosh K. Katiyar, Rajiv R. Mohan et al. · PubMed · 1999 · 211 citations

Medicine, Oncology, Pharmacology +15

Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention

Jifu Zhao, Rajesh Agarwal · Carcinogenesis · 1999 · 175 citations

Medicine, Oncology, Pharmacology +14

Method for Determining the Solubilities of Hydrophobic Organics in Subcritical Water

David J. Miller, Steven B. Hawthorne · Analytical Chemistry · 1998 · 174 citations

Natural Sciences, Chemistry, Analytical Chemistry +9

Novel Cancer Chemopreventive Effects of a Flavonoid Antioxidant Silymarin: Inhibition of mRNA Expression of an Endogenous Tumor Promoter TNFα

Xiaolin Zi, Hasan Mukhtar, Rajesh Agarwal · Biochemical and Biophysical Research Communications · 1997 · 107 citations

Medicine, Oncology, Pharmacology +17