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Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis

Medicinal ChemistryBiochemistryProtein AssemblyNatural SciencesMedicineCyclic SulfonamideRational Drug DesignProtein X-ray CrystallographyMolecular BiologyX-ray Crystallographic AnalysisStructural OptimizationChemical BiologyMolecular DockingMolecular ModelingStructural BiologyDrug Discovery