Time efficient detection of protein–ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment

<i>Principles of Nuclear Magnetic Resonance in One and Two Dimensions</i>

Richard R. Ernst, Geoffrey Bodenhausen, Alexander Wokaun et al. · Physics Today · 1989 · 4.2K citations

Natural Sciences, Chemistry, Physics +17

Attenuated <i>T</i> ₂ relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Konstantin Pervushin, Roland Riek, Gerhard Wider et al. · Proceedings of the National Academy of Sciences · 1997 · 2.5K citations · Full text

Natural Sciences, Biochemistry, Physics +14

Discovering High-Affinity Ligands for Proteins: SAR by NMR

Suzanne B. Shuker, Philip J. Hajduk, Robert Meadows et al. · Science · 1996 · 2K citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Gradient-Tailored Water Suppression for 1H-15N HSQC Experiments Optimized to Retain Full Sensitivity

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Natural Sciences, Chemical Engineering, Molecular Physics +4

The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements

Stephan Grzesiek, Ad Bax · Journal of the American Chemical Society · 1993 · 894 citations

Natural Sciences, Biochemistry, Biophysics +7