Enantiospecific conjugate addition of N-nucleophiles to substituted fumaric acids using methylasparase

Abstract

In addition to ammonia, 3-methylaspartase is able to catalyse the conjugate addition of hydrazine, hydroxylamine, methoxylamine and alkylamines to various alkyl- and halogenofumaric acids to give single enantiomers of the corresponding N-substituted aspartic acids.