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Computerized scintigraphic technique for the evaluation of adult respiratory distress syndrome: initial clinical trials.
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1982
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AsthmaHeart FailureRespiratory Distress Syndrome (Pulmonary Critical Care)Initial Clinical TrialsDiagnosisAcute Respiratory Distress SyndromePositive Slope IndexPublic HealthAcute MedicineCardiologyRadiologyCardiovascular ImagingVentilationRespiratory Distress Syndrome (Neonatal Medicine)Pulmonary MedicineComputerized Scintigraphic TechniqueLung CancerPulmonary Vascular DiseasePulmonary DiseaseEmergency MedicineCardiovascular DiseasePatient SafetyEleven PatientsMedicineSlope Index
Eleven patients with suspected adult respiratory distress syndrome (ARDS) and five control patients were studied using a computerized gamma imaging and analysis technique and 99mTc-labeled human serum albumin. The heart and right lung were imaged, lung:heart ratio was plotted vs. time, and a linear regression was fitted to the data points displayed. The slope of this fit was termed the "slope index." An index value of 2 standard deviations greater than the control mean was considered positive. Radiographs from the six positive studies revealed typical diffuse air-space disease. Radiographs from two of the five negative studies demonstrated air-space consolidation. Both of these patients had elevated pulmonary capillary wedge pressure, cardiomegaly, and clinical course consistent with cardiogenic pulmonary edema. These preliminary data demonstrated a good correlation between positive slope index and clinical ARDS.