Recombinant hirudin: A specific thrombin inhibiting anticoagulant for hemodialysis

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

T.J. Rydel, Kirubhagaran Ravichandran, A. Tulinsky et al. · Science · 1990 · 714 citations

Subcutaneous Low-Molecular-Weight Heparin Compared with Continuous Intravenous Heparin in the Treatment of Proximal-Vein Thrombosis

Russell D. Hull, Gary E. Raskob, Graham F. Pineo et al. · New England Journal of Medicine · 1992 · 705 citations · Full text

Effects of thrombin inhibition on the development of acute platelet-thrombus deposition during angioplasty in pigs. Heparin versus recombinant hirudin, a specific thrombin inhibitor.

M. Heras, James H. Chesebro, W J Penny et al. · Circulation · 1989 · 332 citations · Full text

Specific Thrombin Inhibitor, Surgery, Biomedical Engineering +18

Bleeding associated with antithrombotic therapy.

Kelton Jg, J. Hirsh · PubMed · 1980 · 150 citations

Gastrointestinal Bleeding, Thrombosis, Antithrombotic Therapy +7

Evaluation of the inhibition by heparin and hirudin of coagulation activation during r-tPA-induced thrombolysis

Massoud Mirshahi, J. Soria, C. Soria et al. · Blood · 1989 · 117 citations · Full text