Diterpenoid total synthesis, XXXI. Synthesis and absolute configuration of (−)‐stypoldione, a metabolite of <i>Stypopodium zonale</i>

Abstract

Abstract ( S )‐3‐Hydroxy‐2,2‐dimethylcyclohexanone ( 2 ) was converted to (−)‐stypoldione ( 1 ), the ichthyotoxic and cytotoxic metabolite of the brown alga Stypopodium zonale . The present synthesis established the absolute configuration of (−)‐stypoldione as depicted in 1 .