Concepedia

5-Aminolevulinic Acid Induced Fluorescence Is a Powerful Intraoperative Marker for Precise Histopathological Grading of Gliomas with Non-Significant Contrast-Enhancement

Georg Widhalm, Barbara Kiesel, Adelheid Wöehrer, Tatjana Traub‐Weidinger, Matthias Preusser, Christine Marosi, Daniela Prayer, Johannes A. Hainfellner, Engelbert Knosp, Stefan Wolfsberger

PLoS ONE · 2013 · 161 citations · 39 references

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Abstract

Our study indicates that 5-ALA induced PpIX fluorescence is a powerful marker for intraoperative identification of anaplastic foci according to the histopathological WHO criteria in DIG with non-significant contrast-enhancement. Therefore, application of 5-ALA optimizes tissue sampling for precise histopathological diagnosis independent of brain-shift.

References

39

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Roger Stupp, Warren Mason, Martin J. van den Bent et al. · New England Journal of Medicine · 2005 · 21K citations · Full text

Erratum to: The 2007 WHO classification of tumours of the central nervous system

David N. Louis, Hiroko Ohgaki, Otmar D. Wiestler et al. · Zurich Open Repository and Archive (University of Zurich) · 2007 · 4.5K citations

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial

Walter Stummer, Uwe Pichlmeier, Thomas R. Meinel et al. · The Lancet Oncology · 2006 · 3.3K citations

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Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas

Justin S. Smith, Edward F. Chang, Kathleen R. Lamborn et al. · Journal of Clinical Oncology · 2008 · 1.3K citations · Full text

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

Emilia S. Olson, Tao Jiang, Todd A. Aguilera et al. · Proceedings of the National Academy of Sciences · 2010 · 561 citations · Full text