Journal of Neuropsychiatry · 2004 · 114 citations · 7 references
MedicineNeurosciencePsychiatryNeurochemistryNeuropsychiatryNeuropsychologyAttention DisordersAttention-deficit/hyperactivity DisorderCognitive NeuropsychologyNeurodevelopmental DisordersPediatric NeuropsychiatryPediatric NeuropsychologyAdhd NeurobiologyAttention Deficit Hyperactivity Disorder ComorbidityBetween-group ComparisonChildhood AdhdFrontal Lobe NeuroimagingMagnetic ResonanceNeuropsychological ImpairmentNuclear Magnetic Resonance Spectroscopy
Proton magnetic resonance spectroscopy (MRS) and neuropsychological testing were conducted on 8 children with attention-deficit/hyperactivity disorder (ADHD-H), with no learning disabilities or comorbidities and 8 controls. Magnetic resonance spectroscopy revealed increased Glutamate/Glutamine in both frontal areas, and increased N-acetyl aspartate and Choline in the right frontal area of the ADHD-H subjects. Neuropsychological testing revealed few within- and between-group differences. Findings related to frontal lobe dysfunction in ADHD-H subjects were noted. N-acetylasparte/creatine (NAA/Creatine) in the right frontal region, and myoinositol/creatine (Myo inositol/Creatine) in the right and left frontal regions appear to be highly associated with the regulation of sensorimotor, language, and memory and learning functioning in children with ADHD-H.
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B. J. Casey, F. Xavier Castellanos, Jay N. Giedd et al. · Journal of the American Academy of Child & Adolescent Psychiatry · 1997 · 811 citations · Full text