Rare Human Nicotinic Acetylcholine Receptor α4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine Receptors

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Marina R. Picciotto, Michèle Zoli, Roberto Rimondini et al. · Nature · 1998 · 1.3K citations

Life Sciences, Neuroscience, Pharmacology +16

A Mutation in the Vesicle-Trafficking Protein VAPB Causes Late-Onset Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis

Agnes L. Nishimura, Miguel Mitne‐Neto, Helga Cristina Almeida da Silva et al. · The American Journal of Human Genetics · 2004 · 979 citations · Full text

Life Sciences, Neurology, Neuroscience +12

Nicotine Activation of α4* Receptors: Sufficient for Reward, Tolerance, and Sensitization

Andrew R. Tapper, Sheri McKinney, Raad Nashmi et al. · Science · 2004 · 688 citations

Medicine, Neuroscience, Pharmacology +17

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

Marina R. Picciotto, Michèle Zoli, Clément Léna et al. · Nature · 1995 · 664 citations

Life Sciences, Neuroscience, Pharmacology +14

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

Laura J. Bierut, Jerry A. Stitzel, Jen C. Wang et al. · American Journal of Psychiatry · 2008 · 639 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17