Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +7

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.8K citations

Engineering, Natural Sciences, Rna Isolation +7

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Hitoshi Shimano, Jay D. Horton, Iichiro Shimomura et al. · Journal of Clinical Investigation · 1997 · 831 citations · Full text

Fatty Liver Disease, Transgenic Mice, Transcriptional Regulation +19

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Hitoshi Shimano, Jay D. Horton, Robert E. Hammer et al. · Journal of Clinical Investigation · 1996 · 815 citations · Full text

Fatty Liver Disease, Transgenic Mice, Cellular Physiology +22

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Iichiro Shimomura, Robert E. Hammer, James A. Richardson et al. · Genes & Development · 1998 · 796 citations · Full text