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C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by c-jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma

Karen Man‐Fong Sze, Glanice K.Y. Chu, Joyce M.F. Lee, Irene Oi‐Lin Ng

Hepatology · 2012 · 140 citations · 28 references

DOIFull text

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Abstract

Our data suggest that COOH truncation of HBx, particularly with 24 amino acids truncated at the C-terminal end, plays a role in enhancing cell invasiveness and metastasis in HCC by activating MMP10 through C-Jun.

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