Quantitative Structure-Activity Relationships · 1989 · 14 citations · 18 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryDrug InteractionsStructure-activity RelationshipsDrug-drug InteractionsDrug-receptor InteractionsLigand BindingMolecular ModelingQuantitative Structure-activity RelationshipsStructure-activity Relationship AnalysisComputational Structure-activity ModelingDrug - Membrane InteractionsDrug-target Interaction AnalysisMolecular Property-based DesignMultivariate Data AnalysisMultivariate Data ExplorationStructure-activity Relationship Modeling
Abstract Amphiphilic drugs of various structures are known to interact with phospholipids. Simple benzylamines have been used as probes to test the structural influence on the degree of interaction. This interaction has been quantified with various methods as for example NMR‐binding measurements, scanning calorimetry, inhibition of Ca ++ ‐incorporation, negative inotropic effect and antimycobacterial activity. Multiregression and multivariate data analysis have been performed and the results are discussed.
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