Concepedia

Alzheimer's disease gene signature says: beware of brain viral infections

Elisa Porcellini, Ilaria Carbone, Manuela Ianni, Federico Licastro

Immunity & Ageing · 2010 · 59 citations · 36 references

DOIFull text

Open access

Abstract

We hypothesized that such genetic trait may predispose to AD via complex and diverse mechanisms each contributing to an increase of individual susceptibility to brain viral infections.

References

36

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Denise Harold, Richard Abraham, Paul Hollingworth et al. · Nature Genetics · 2009 · 3.4K citations · Full text

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

Nature Genetics · 2009 · 2.2K citations · Full text

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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Stephanie J. Soscia, James E. Kirby, Kevin J. Washicosky et al. · PLoS ONE · 2010 · 1K citations · Full text

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

Robert W. Mahley, Karl H. Weisgraber, Yadong Huang · Journal of Lipid Research · 2008 · 559 citations · Full text

Herpes simplex virus

Rebecca W. Widener, Richard J. Whitley · Handbook of clinical neurology · 2014 · 474 citations

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