Phytotherapy Research · 2005 · 69 citations · 4 references
PharmacyPharmacologyPlant SciencesHepatologyHepatotoxicologyPlant BiochemistryHepatic ImpairmentHepatic MetabolismHepatic ToxicityHepatotoxicity MechanismsLiver DiseaseToxic PlantsHepatoprotective AgentsHepatotoxic Plant CompoundsHepatotoxic PlantsHerbal Medicine HepatotoxicityHerbal ToxicityHerbal-induced Liver InjuryNatural Product HepatotoxicitySuccinate Metabolism
The effect of ten phytotherapeutic products on CCl(4) intoxicated liver in albino male Wistar rats was investigated. Biochemical parameters, including serum transaminase activity (GPT and GOT), histoenzymological measurements (lactate dehydrogenase, LDH; succinate dehydrogenase, SDH, cytochromoxidase, CyOx; Mg(2+)-dependent adenosine triphosphatase, ATP-ase) and histochemical (Sudan black) and histological examinations (haematoxylin-eosin staining) of the liver were investigated. Some positive effects such as the reduction of hepatocytolysis and steatosis, and a return to normal values of the activity of some enzymes in the following plants: Chrysanthemum balsamita, Echinacea pallida, Calendula officinalis and Corylus avelana were obtained.
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