Physiological levels of HBB transgene expression from S/MAR element-based replicating episomal vectors

Selective extraction of polyoma DNA from infected mouse cell cultures

Bernhard Hirt · Journal of Molecular Biology · 1967 · 5.3K citations

Xenotransplantation, Molecular Biological Method, Medicine +11

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

Dale Talbot, P. Collis, Michael Antoniou et al. · Nature · 1989 · 333 citations · Full text

Transcriptional Regulation, Systems Biology, Dominant Control Region +7

Intergenic transcription and transinduction of the human β-globin locus

Hilary L. Ashe, Joan Monks, Mark Wijgerde et al. · Genes & Development · 1997 · 326 citations · Full text

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

Phil Collis, Michael Antoniou, Frank Grosveld · The EMBO Journal · 1990 · 323 citations · Full text

Transcriptional Regulation, Systems Biology, Minimal Requirements +9

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells

Christoph Piechaczek, Christiane Fetzer, Armin Baiker et al. · Nucleic Acids Research · 1999 · 211 citations · Full text

Sv40 Origin, Genetics, Antigen Processing +19