The <i>COMT</i> Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial - Concepedia

Concepedia

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The <i>COMT</i> Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial

95

Citations

18

References

2010

Year

Jean‐Christophe Corvol, Cécilia Bonnet, Fanny Charbonnier‐Beaupel, Marie‐Hélène Fiévet, Agnès Bellanger, Emmanuel Roze, Gayané Meliksetyan, Mouna Ben Djebara, Andréas Hartmann, Lucette Lacomblez,

Annals of Neurology

Abstract

The COMT(HH) genotype in PD patients enhances the effect of entacapone on the pharmacodynamics and pharmacokinetics of levodopa. The response to entacapone after repeated administrations and in heterozygous patients remains to be determined.

References

	Year	Citations

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