Enteric Protein Loss with Hypoproteinemia in Diffuse Lymphosarcoma of the Bowel

Abstract

Case Studies1 August 1963Enteric Protein Loss with Hypoproteinemia in Diffuse Lymphosarcoma of the BowelDAVID WERDEGAR, M.D., HOWARD ADLER, M.D., CHARLES WATLINGTON, M.D.DAVID WERDEGAR, M.D.Search for more papers by this author, HOWARD ADLER, M.D.Search for more papers by this author, CHARLES WATLINGTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-2-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypoproteinemia due to gastrointestinal loss of protein has been reported in association with many pathologic conditions of stomach and bowel (1). Disorders in which "protein-losing gastroenteropathy" (2) has been described include giant hypertrophy of the gastric mucosa (3), adenocarcinoma of the stomach (4), regional ileitis and ulcerative colitis (5, 6,), granulomatous disease of the small bowel (6), nontropical (7, 8) and tropical sprue (9), intestinal lymphangiectasia (10), and Whipple's disease (11). Although hypoproteinemia has occasionally been found in patients with lymphomatous disease of the bowel (6, 12, 13), we know of no well-documented case in which the mechanism of the...References1. JEFFRIESHOLMANSLEISENGER GHHRMH: Plasma proteins and the gastrointestinal tract. New Eng. J. Med. 266: 652, 1962. CrossrefMedlineGoogle Scholar2. Editorial: Protein-losing gastroenteropathy. Lancet 1: 351, 1959. MedlineGoogle Scholar3. CITRINSTERLINGHALSTED YKJA: The mechanism of hypoproteinemia associated with giant hypertrophy of the gastric mucosa. New Eng. J. Med. 257: 906, 1957. CrossrefMedlineGoogle Scholar4. JARNUMSCHWARTZ SM: Hypoalbuminemia in gastric carcinoma. Gastroenterology 38: 769, 1960. CrossrefMedlineGoogle Scholar5. STEINFELDDAVIDSONGORDONGREENE JLJDRSFE: The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis. Amer. J. Med. 29: 405, 1960. CrossrefMedlineGoogle Scholar6. SCHWARTZJARNUM MS: Protein-losing gastroenteropathy: hypoproteinaemia due to gastrointestinal protein loss of varying aetiology, diagnosed by means of 131I-albumin. Danish Med. Bull. 8: 1, 1961. MedlineGoogle Scholar7. PARKINS RA: Protein-losing enteropathy in the sprue syndrome. Lancet 2: 1366, 1960. CrossrefMedlineGoogle Scholar8. LONDONBAMFORTHCREAMER DRJB: Steatorrhoea presenting with gastrointestinal protein loss. Lancet 2: 18, 1961. CrossrefMedlineGoogle Scholar9. RUBINISHEEHYMERONEYLOURO METWWHJ: Exudative enteropathy. II. Observations in tropical sprue. J. Lab. Clin. Med. 58: 902, 1961. MedlineGoogle Scholar10. HOLMANNICKELSLEISENGER HWFMH: Hypoproteinemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Amer. J. Med. 27: 963, 1959. CrossrefMedlineGoogle Scholar11. HOLLENBERG M: Whipple's disease: a case report, with enzyme histochemical and electron microscopic findings. Amer. J. Med. 32: 448, 1962. CrossrefMedlineGoogle Scholar12. SLEISENGERALMYBARR MHTPDP: The sprue syndrome secondary to lymphoma of the small bowel. Amer. J. Med. 15: 666, 1953. CrossrefMedlineGoogle Scholar13. BARANDUNAEBERSOLDBIANCHIKLUTHEVON MURALTPORETTIRIVA SJRRGGG: "Proteindiarrhöe." Zugleich ein Beitrag zur Frage der sogenannten essentiellen Hypoproteinämie. Schweiz. Med. Wschr. 90: 1458, 1960. MedlineGoogle Scholar14. GILMOREROBBINSREID RCMCAF: Labeling bovine and human albumin with I131. Nucleonics 12: 65, 1954. Google Scholar15. ROSENBERGDIAMONDJASLOWITZCRAVER SAHDBLF: Lymphosarcoma: a review of 1269 cases. Medicine 40: 31, 1961. CrossrefMedlineGoogle Scholar16. WOLFMARSHAK BSRH: Roentgen features of diffuse lymphosarcoma of the colon. Radiology 75: 733, 1960. CrossrefMedlineGoogle Scholar17. MARSHAKWOLFELIASOPH RHBSJ: The roentgen findings in lymphosarcoma of the small intestine. J. Mount Sinai Hosp. N. Y. 24: 1032, 1957. MedlineGoogle Scholar18. GORDON RS: Exudative enteropathy: abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinyl-pyrrolidone. Lancet 1: 325, 1959. CrossrefMedlineGoogle Scholar19. RASMUSSENREIFENSTEIN HEC: The parathyroid glands, in Textbook of Endocrinology, 3rd ed., ed. by WILLIAMS, R. H., W. B. Saunders Company, Philadelphia, 1962, p. 739. Google Scholar20. MILHAUDVESIN GP: Calcium metabolism in man with calcium-45: malabsorption syndrome and exudative enteropathy. Nature 191: 872, 1961. CrossrefMedlineGoogle Scholar21. RICHMONDSHERMANDIAMONDCRAVER JRSHDLF: Renal lesions associated with malignant lymphomas. Amer. J. Med. 32: 184, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, CaliforniaFrom the Department of Medicine, University of California School of Medicine, San Francisco, California.Requests for reprints should be addressed to Editorial Office, Department of Medicine, University of California Medical Center, San Francisco 22, California. 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JACKSON JR., M.D., CARL PETERSON JR., M.D.Protein-losing enteropathyReversible Protein-Losing Enteropathy with Intestinal Lymphangiectasia Secondary to Chronic Constrictive Pericarditis 1 August 1963Volume 59, Issue 2Page: 207-214KeywordsEdemaExcretionGastric mucosaGastroenterology and hepatologyHypoproteinemiaInflammatory bowel diseaseProteinsStomachTropical diseasesUlcerative colitis Issue Published: 1 August 1963 PDF downloadLoading ...