Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells <i>in vitro</i> by inducing G₁ arrest and apoptosis

Abstract

The new benzylidene derivatives of andrographolide are potential anticancer agents. SRJ09 emerged as the lead compound in this study, exhibiting anticancer activity by downregulating CDK4 to promote a G(1) phase cell cycle arrest, coupled with induction of apoptosis.