Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

Gail Urlaub, Emmanuel Käs, Adelaide M. Carothers et al. · Cell · 1983 · 294 citations · Full text

Life Sciences, Genetics, Molecular Genetics +7

Consensus perspectives on prophylactic therapy for haemophilia: summary statement

Erik Berntorp, Jan Astermark, Sven Björkman et al. · Haemophilia · 2003 · 270 citations · Full text

Medicine, Hematology, Pharmacotherapy +12

Guideline on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders

David Keeling, Robert C. Tait, Michael Makris · Haemophilia · 2008 · 258 citations

Medicine, Hematology, Pharmacotherapy +16

Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.

Randal J. Kaufman, L C Wasley, B Furie et al. · Journal of Biological Chemistry · 1986 · 229 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Identification of the Phospholipid Binding Site in the Vitamin K-dependent Blood Coagulation Protein Factor IX

Steven J. Freedman, Mark Blostein, James Baleja et al. · Journal of Biological Chemistry · 1996 · 131 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15