Journal of the American Chemical Society · 2003 · 345 citations · 1 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganic ChemistryCatalyst DesignCatalyst SynthesisCatalytic MaterialsCross-coupling ReactionsMetal CatalysisAlkenyl Halide CouplingAlkyl Cross-couplingCross-coupling CatalysisNegishi CouplingNickel CatalysisNickel CatalystsNickel-catalyzed Cross-couplingPalladium-catalyzed Cross-coupling
The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides.
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