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Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands

Neil R. Curtis, Janusz J. Kulagowski, Paul D. Leeson, Mark P. Ridgill, Frances Emms, Stephen B. Freedman, Shil Patel, Smita S. Patel

Bioorganic & Medicinal Chemistry Letters · 1999 · 45 citations · 12 references

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12

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

Hubert H.M. Van Tol, James R. Bunzow, Hong‐Chang Guan et al. · Nature · 1991 · 2K citations · Full text

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Synthesis of indoles via palladium-catalyzed heteroannulation of internal alkynes

Richard C. Larock · Journal of the American Chemical Society · 1991 · 824 citations

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Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

P Seeman · PubMed · 1992 · 441 citations

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3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D<sub>4</sub> Receptor

Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis et al. · Journal of Medicinal Chemistry · 1996 · 257 citations · Full text

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The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia

Mark S. Kramer · Archives of General Psychiatry · 1997 · 199 citations

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