Diagnosis of 6 Mercaptopurine Hepatotoxicity Post Liver Transplantation Utilizing Metabolite Assays

A method for estimating the probability of adverse drug reactions

C. A. Naranjo, U. Busto, Edward M. Sellers et al. · Clinical Pharmacology & Therapeutics · 1981 · 11.4K citations

Diagnosis, Pharmacotherapy, Logistic Analysis +28

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

Marla C. Dubinsky, Stéphanie Lamothe, Hui Ying Yang et al. · Gastroenterology · 2000 · 1K citations

Inflammation, Metabolite Measurement, Anti-inflammatory +8

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease

Marla C. Dubinsky, Huiying Yang, Philip V. Hassard et al. · Gastroenterology · 2002 · 483 citations · Full text

Inflammation, 6-Mp Metabolite Profiles, Medicine +10

Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease

Carmen Cuffari, Sarah Hunt, T. M. Bayless · Gut · 2001 · 308 citations · Full text