Concepedia

Multiple Sialyl Lewis<sup>x</sup> N‐Glycopeptides: Effective Ligands for E‐Selectin

Ulrich Sprengard, Manfred Schudok, Wolfgang Schmidt, Gerhard Kretzschmar, Horst Kunz

Angewandte Chemie International Edition in English · 1996 · 105 citations · 23 references

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Abstract

Threefold condensation of the sialyl Lewisx amine derivative 1 with cyclopeptides leads to multivalent glycopeptides with repetitive saccharide units. A trivalent sialyl Lewisx N-glycopeptide proved to be a potent antagonist of E-selectin.

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