Publication | Open Access
Multiple Sialyl Lewis<sup>x</sup> N‐Glycopeptides: Effective Ligands for E‐Selectin
105
Citations
23
References
1996
Year
Molecular RecognitionMedicinal ChemistryPotent AntagonistBiochemistryThreefold CondensationNatural SciencesMedicineGlycobiologyMechanism Of ActionCyclopeptides LeadsCarbohydrate-protein InteractionNon-peptide LigandChemical BiologyPharmacologyEffective LigandsDrug DiscoveryGlycosylation
Threefold condensation of the sialyl Lewisx amine derivative 1 with cyclopeptides leads to multivalent glycopeptides with repetitive saccharide units. A trivalent sialyl Lewisx N-glycopeptide proved to be a potent antagonist of E-selectin.
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