Concepedia

Prodrugs of peptides. 10. Protection of di- and tripeptides against aminopeptidase by formation of bioreversible 4-imidazolidinone derivatives

Gitte Juel Rasmussen

International Journal of Pharmaceutics · 1991 · 23 citations · 13 references

Concepts

PharmacyBiochemistryMedicinal ChemistryDrug DiscoveryEnzymologyProdrug DesignAmino Acid ProdrugsEnzymatic Cleavage StrategiesPeptide ChemistryPeptide Drug DiscoveryPeptide ProdrugsProteolytic EnzymesDipeptide ProdrugsPeptide Prodrug DesignPeptide-directed Prodrugs

References

13

Proteinases in mammalian cells and tissues

J. Kay · FEBS Letters · 1978 · 825 citations

Life Sciences, Biochemistry, Cell Biology +12

Penetration and enzymatic barriers to peptide and protein absorption

Vincent H.L. Lee, Akira Yamamoto · Advanced Drug Delivery Reviews · 1989 · 408 citations

Pharmacy, Biochemistry, Pharmacokinetics +12

Aminopeptidase activity in homogenates of various absorptive mucosae m the albino rabbit: implications in peptide delivery

Robert E. Stratford, Vincent H.L. Lee · International Journal of Pharmaceutics · 1986 · 124 citations

Life Sciences, Biochemistry, Protein Biochemistry +10

Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme

Judi Møss · Pharmaceutical Research · 1990 · 77 citations

Pharmacy, Biochemistry, Pharmacology +16

(C) Means to enhance penetration

Advanced Drug Delivery Reviews · 1992 · 68 citations

Computing, Computer Science, Computer Security +5