Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

S. E. Luria, M. Delbrück · Genetics · 1943 · 3.9K citations

Life Sciences, Genetics, Microbiology +17

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Masamichi Muramatsu, V.S. Sankaranand, Shrikant Anant et al. · Journal of Biological Chemistry · 1999 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Somatic hypermutagenesis in immunoglobulin genes

Igor B. Rogozin · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 1992 · 459 citations

Life Sciences, Genetics, Molecular Genetics +14

DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Xianmin Zeng, David B. Winter, Cynthia Kasmer et al. · Nature Immunology · 2001 · 419 citations

Life Sciences, Genetics, Molecular Genetics +12