Fabrication of low-cost electronic biosensors

TLDR

Miniaturized, low‑cost flexible sensors made from organic electronics using high‑throughput printing techniques are rapidly advancing, offering improved sensitivity, stability, specificity, and broad chemical detection capabilities. This review examines fabrication, challenges, and performance of organic transistor‑based sensors, aiming to guide development of devices for biologically relevant media. The authors survey fabrication strategies, identify challenges, and evaluate sensor performance of organic transistor‑based detection devices.

Abstract

The fabrication of miniaturized, low-cost, flexible sensors based on organic electronics via high-throughput techniques (e.g. printing) is expected to provide important benefits for applications in chemical and biological detection. The rapid maturation of synthetic methodology in the field of organic electronics has lead to the creation of new materials at an incredible rate and an increased understanding of semiconductor-analyte interactions. Owing to these advances, we have seen steady improvements in sensitivity, stability, and specificity, in addition to the detection of a wide range of chemical analytes. In this review, we address the fabrication, challenges, and sensor performance of organic transistor-based detection devices with an outlook toward developing sensors capable of operating in biologically relevant media.