Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitors

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

Bioorganic Chemistry, Chemical Biology, Molecular Pharmacology +17

The Diagnosis of Bleeding Disorders.

Annals of Internal Medicine · 1975 · 117 citations · Full text

Gastrointestinal Bleeding, Thrombosis, Hematology +8

THE PARTIAL THROMBOPLASTIN TIME AS A SCREENING TEST FOR THE DETECTION OF LATENT BLEEDERS

Sylvanus W. Nye, John B. Graham, K. M. Brinkhous · The American Journal of the Medical Sciences · 1962 · 96 citations

Thrombosis, Venous Thrombosis, Health Sciences +13

Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases

J. D. Geratz, Frank M. Stevens, Kenneth L. Polakoski et al. · Archives of Biochemistry and Biophysics · 1979 · 50 citations

Protein Chemistry, Biochemistry, Protein Assembly +10

Synthetic inhibitors of serine proteinases XIV. Inhibition of factor Xa by derivatives of benzamidine

Jörg Stürzebecher, F Markwárdt, P Walsmann · Thrombosis Research · 1976 · 37 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +11