The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity

Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.

M Bubb, Adrian M. Senderowicz, Edward A. Sausville et al. · Journal of Biological Chemistry · 1994 · 818 citations · Full text

Life Sciences, Cell Biology, Pharmacology +15

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

Junyi Ma, Liang Guo, Steve Fiene et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2011 · 802 citations · Full text

Medicine, Cardiology, Physiology +16

Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation

Timothy M. Olson, Alexey E. Alekseev, Xiaoke Liu et al. · Human Molecular Genetics · 2006 · 495 citations · Full text

Life Sciences, Cardiology, Genetics +17

Jasplakinolide, a cyclodepsipeptide from the marine sponge, SP.

Phillip Crews, L. Manes, Mark A. Boehler · Tetrahedron Letters · 1986 · 317 citations

Life Sciences, Marine Biology, Marine Sciences +6

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

Liang Guo, Rory Abrams, Joshua Babiarz et al. · Toxicological Sciences · 2011 · 273 citations · Full text

Medicine, Cardiology, Pharmacology +13