HLA–C Antigens on Platelets¹

Abstract

The direct demonstration of HLA-C antigens Cw2, Cw-3, and Cw4 on human platelets is described. The antigens were detected by means of a platelet radioimmune anti-IgG test using acid eluates from platelets and lymphocytotoxic antisera. It is concluded that HLA-C determinants are only weakly expressed on platelets. Individual differences observed reflect antigenic variations.