Characterization of the Isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

Marek W. Radomski, Richard Palmer, Salvador Moncada · Biochemical and Biophysical Research Communications · 1987 · 758 citations

Medicine, Cell Biology, Hematology +16

Multiple cyclic nucleotide phosphodiesterases.

Joseph A. Beavo, Marco Conti, Richard J. Heaslip · Molecular Pharmacology · 1994 · 477 citations

Life Sciences, Biochemistry, Molecular Biology +10

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

M. L. REEVES, B. K. Leigh, P. England · Biochemical Journal · 1987 · 304 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators.

Maria Halbrügge, Claudia B Friedrich, Martin Eigenthaler et al. · Journal of Biological Chemistry · 1990 · 271 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterases in Homogenates and Tissue Slices from Rat Brain

Ulrich Schwabe, M. Miyake, Y Ohga et al. · Molecular Pharmacology · 1976 · 219 citations

Medicine, Neurobiology, Pharmacology +14