Concepedia

Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection

Pierre–Yves Bochud, Martin Hersberger, Patrick Taffé, Murielle Bochud, Catherine M. Stein, Stéphanie Rodrigues, Thierry Calandra, P Francioli, Amalio Telenti, Roberto F. Speck,

AIDS · 2007 · 162 citations · 22 references

DOI

Abstract

Rapid progression of HIV-1 infection was associated with TLR9 polymorphisms. Because of its potential implications for intervention strategies and vaccine developments, additional epidemiological and experimental studies are needed to confirm this association.

References

22

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Toll-like Receptors, Virulence Factor, Pathogenesis +7

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

Rong Liu, William A. Paxton, Sunny Choe et al. · Cell · 1996 · 3.1K citations · Full text

Primary Immunodeficiency, Hiv-1 Coreceptor Accounts, Homozygous Defect +9

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

Michel Samson, Frédérick Libert, Benjamin J. Doranz et al. · Nature · 1996 · 2.9K citations

Primary Immunodeficiency, Human Retrovirus, Mutant Alleles +8

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the <i>CKR5</i> Structural Gene

Michael Dean, Mary Carrington, Cheryl A. Winkler et al. · Science · 1996 · 2.5K citations

A Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping

Bernie Devlin, Neil Risch · Genomics · 1995 · 1K citations · Full text