Concepedia

Manganese-mediated up-regulation of HIF-1α protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs

Hee-Jung Shin, Mi‐Sun Choi, Nam Hee Ryoo, Ki-Young Nam, Gy-Young Park, Jae‐Hoon Bae, Seong‐Il Suh, Won‐Ki Baek, Jong‐Wook Park, Byeong‐Churl Jang

Toxicology in Vitro · 2010 · 27 citations · 34 references

DOIFull text

Open access

Concepts

References

34

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Regulation of hypoxia-inducible factor 1α is mediated by an O <sub>2</sub> -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

, , +15

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Susana Alicia Salceda, J. Jaime · Journal of Biological Chemistry · 1997 · 1.7K citations · Full text

, , +15