Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents

A convenient synthesis of quinones from hydroquinone dimethyl ethers. Oxidative demethylation with ceric ammonium nitrate

Peyton Jacob, Patrick S. Callery, Alexander T. Shulgin et al. · The Journal of Organic Chemistry · 1976 · 284 citations

Derivative (Chemistry), Hydroquinone Dimethyl Ethers, Pharmacology +8

Discovery of (<i>R</i>)-7-Cyano-2,3,4,5-tetrahydro-1-(1<i>H</i>-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1<i>H</i>-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity

John T. Hunt, Charles Z. Ding, Roberta S. Batorsky et al. · Journal of Medicinal Chemistry · 2000 · 134 citations · Full text

Medicinal Chemistry, -1,4-Benzodiazepine Farnesyltransferase, Biochemistry +15

Synthesis and antiproliferative activity of some benzimidazole-4,7-dione derivatives

Laura Garuti, Marinella Roberti, Monica Malagoli et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 86 citations

Derivatives, Organic Chemistry, Pharmacology +2

Indolequinone Antitumor Agents:  Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity

Howard D. Beall, Shannon L. Winski, Elizabeth Swann et al. · Journal of Medicinal Chemistry · 1998 · 84 citations

Bioorganic Chemistry, Aldo-keto Reductase, Heterocycle Chemistry +19

Aziridinyl Quinone Antitumor Agents Based on Indoles and Cyclopent[<i>b</i>]indoles:  Structure−Activity Relationships for Cytotoxicity and Antitumor Activity

Edward B. Skibo, Chengguo Xing, Robert T. Dorr · Journal of Medicinal Chemistry · 2001 · 73 citations