Science · 1980 · 112 citations · 12 references
Life SciencesInfectious DiseasesPharmacologyImmunology Of Infectious DiseasesMolecular VirologyVirologyAntiviral AgentsAntiviral ImmunityAntiviral PharmacologyInterferon ResponsesViral InfectionsViral PathogenesisAntiviral Interferon ResponsesDirect-acting AntiviralsInhibition Of Interferon ResponsesInterference With Interferon SignalingInterferon ProductionInterferon Response To Viral InfectionInterferon-mediated Antiviral DefenseType I Interferon Responses
Prostaglandins of the A series strongly inhibit the production of Sendai virus in African green monkey kidney cells and are able to prevent the establishment of persistent infection ("carrier" state). This action is specific for prostaglandin A and is not due to alteration in the host cell metabolism or in the virus infectivity. The possibility that this effect is mediated by interferon is discussed.
12