Age-related methylation in normal colon mucosa differs between the proximal and distal colon in patients who underwent colonoscopy

CpG island methylator phenotype in colorectal cancer

Minoru Toyota, Nita Ahuja, Mutsumi Ohe-Toyota et al. · Proceedings of the National Academy of Sciences · 1999 · 2.5K citations

Medicine, Genetics, Oncology +17

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

Andrew P. Feinberg, Bert Vogelstein · Nature · 1983 · 2.4K citations

Medicine, Genetics, Molecular Genetics +13

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

Stephen B. Baylln, James G. Herman, Jeremy R. Graff et al. · Advances in cancer research · 1997 · 1.9K citations

Medicine, Genetics, Oncology +14

Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma

James G. Herman, Asad Umar, Kornélia Polyák et al. · Proceedings of the National Academy of Sciences · 1998 · 1.9K citations · Full text

Medicine, Genetics, Oncology +17

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

M F Kane, Massimo Loda, Gretchen M. Gaida et al. · PubMed · 1997 · 1.5K citations

Life Sciences, Genetics, Oncology +17