Angewandte Chemie International Edition · 2003 · 83 citations · 27 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst DesignCatalyst PreparationCatalytic MechanismsHeterogeneous CatalysisOrganic SynthesisSolvent-free SynthesisAsymmetric CatalysisEnantioselective CatalysisEnantioselective SynthesisEnantioselectivityOrganic SubstratesSolvent-free CatalysisSolvent-free Processing
Simply mixing the neat substrates and a small amount of the chiral catalyst (0.1–0.01 mol %) under nearly solvent-free conditions makes the enantioselective carbonyl-ene reaction of glyoxylate ester with a variety of olefins proceed smoothly to afford the corresponding α-hydroxy esters in high yields with excellent enantioselectivities [Eq. (1)].
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Asymmetric catalysis in organic synthesis
G. Jenner · Applied Catalysis A General · 1994 · 1.8K citations