Innate Immunity of the Human Newborn Is Polarized Toward a High Ratio of IL-6/TNF-α Production In Vitro and In Vivo

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

Jack Gauldie, Gerard Cox, Heinz Baumann et al. · Journal of Clinical Investigation · 1998 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Pathology +17

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

Felix Yarovinsky, Dekai Zhang, John F. Andersen et al. · Science · 2005 · 1K citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu et al. · Nature · 2004 · 487 citations

Life Sciences, Immunology, Molecular Biology +14

Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF-α Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

Ofer Levy, Kol A. Zarember, René M. Roy et al. · The Journal of Immunology · 2004 · 377 citations · Full text

Life Sciences, Immunology, Pathobiology +17

Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions

M. Makhseed, Raj Raghupathy, Fawaz Azizieh et al. · Human Reproduction · 2001 · 283 citations

Life Sciences, Immunology, Obstetrics +14