Molecular dimensions of the substrate binding site of cytochrome P-448

Ground states of molecules. XXV. MINDO/3. Improved version of the MINDO semiempirical SCF-MO method

Richard C. Bingham, Michael J. S. Dewar, Donald H. Lo · Journal of the American Chemical Society · 1975 · 1.6K citations

Natural Sciences, Chemistry, Physics +10

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

Dene E. Ryan, Daria Korzeniowski, Wayne Levin · Journal of Biological Chemistry · 1979 · 576 citations · Full text

Medicine, Biochemistry, Toxicology +17

ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS

Allan H. Conney, Clarke Davison, Ruth Gastel et al. · Journal of Pharmacology and Experimental Therapeutics · 1960 · 535 citations

Medicine, Pharmacokinetics, Pharmacology +13

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

Anthony Y.H. Lu, R. Kuntzman, Susan West et al. · Journal of Biological Chemistry · 1972 · 354 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

Linda M. Reik, Dene E. Ryan, Wayne Levin · Journal of Biological Chemistry · 1983 · 337 citations · Full text

Medicine, Immunology, Biochemical Pharmacology +11